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Friday, January 10, 2025

How DMSO Treats 'Incurable' Autoimmune and Contractile Issues


Dimethyl sulfoxide (DMSO) is an easy and available naturally occurring chemical that quickly enters the physique by way of the pores and skin and has quite a lot of exceptional therapeutic properties. When it was found, its proponents realized it represented a brand new therapeutic precept in medication and as soon as adopted, would fully change how medication was practiced.

In flip, they carried out hundreds of research demonstrating DMSO’s overwhelming security and efficacy in tons of of hundreds of individuals, however sadly, the FDA carried out a reprehensible marketing campaign towards DMSO1 that ultimately made it turn into a Forgotten Aspect of Drugs.

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Over the past month, I’ve begun presenting that proof. For instance:

  • I confirmed right here how DMSO transforms the administration of strokes, spinal wire accidents, psychological incapacity and quite a lot of circulatory issues (e.g., Raynaud’s, Varicose Veins and Hemorrhoids).
  • I confirmed right here how DMSO treats power ache, arthritis, burns, wounds and traumatic accidents (e.g., sprains and sports activities accidents) right here.
  • I confirmed right here how DMSO is without doubt one of the most secure medical substances in existence.

In flip, colleagues akin to Pierre Kory have begun utilizing DMSO and reporting exceptional outcomes. Likewise, I’ve acquired tons of of extraordinary tales from readers who’ve gotten their lives again because of DMSO (which could be learn right here) and match precisely what the early pioneers of DMSO noticed. In the present day, I’ll give attention to a few of the different crucial makes use of for DMSO.

Word: Whereas I’ve my very own most well-liked manufacturers of DMSO, most formulations work. When buying DMSO, if getting the liquid kind, you will need to ensure the DMSO is of excessive purity and saved in a glass container (the gel kind additionally works and is simpler to use however can also be extra more likely to be irritating and never at all times as potent).

When making use of DMSO topically, you will need to ensure you usually are not allergic to it (with a small pores and skin take a look at), that your pores and skin is clear (so no chemical toxins are by accident absorbed as nicely) and to solely use the utmost focus one’s pores and skin simply tolerates (which generally is 70% however can differ from 30% to 100%).

DMSO and Protein Issues

DMSO provides a groundbreaking method to treating complicated diseases by stabilizing misfolded proteins,2 a key subject in lots of genetic issues. In contrast to expensive medicine that try and handle these issues with restricted success, DMSO’s protein-folding help can deal with a broad vary of circumstances, together with cystic fibrosis,3 amyloidosis4,5,6,7 and even difficult neurological illnesses.8,9,10 DMSO’s impact right here is remarkably common.

Word: Enhancing the physiologic zeta potential (an method we sometimes use to deal with circulatory issues) may stabilize protein folding (whereas worsening it causes aggregation and misfolding). Likewise, DMSO has been proven11 to dissolve quite a few enzymes with out irreversibly inhibiting them, which authors felt recommended DMSO might compensate for genetically faulty enzymes.12

Remarkably, DMSO has proven promise in treating prion illnesses like Creutzfeldt-Jakob,13 Alzheimer’s,14 and Parkinson’s. Testimonials reveal DMSO’s energy, with stories of improved motion, vitality, and coordination. For instance, one reader utilizing it for Parkinson’s skilled lowered stiffness, sooner motion, and improved motor expertise.15

Whereas I’m very open-minded to unconventional medical concepts and knew DMSO might deal with quite a lot of in any other case incurable neurological illnesses (e.g., ALS), there was one factor I at all times had a little bit of problem believing.

DMSO allegedly had been proven to remedy Down Syndrome, demonstrated each in three medical trials16,17,18 and noteworthy case stories19 that have been introduced by a number of corroborating medical witnesses in Congressional testimony, together with quite a few research exhibiting DMSO improved the cognition and habits of developmentally delayed kids.20,21,22,23

To clarify this not possible profit, I theorized it was probably on account of DMSO’s protein stabilizing advantages, as Down Syndrome is characterised by “the aberrant accumulation of unfolded/misfolded proteins ensuing from over-burdened protein high quality management techniques.”24

What I discover significantly noteworthy about that is that the “untreatability” of genetic issues (which generally end result from a dysfunctional protein) has justified spending unbelievable quantities of cash on each analysis and coverings for them (e.g., the trade continues to be in its early levels however 20.4 billion is already spent every year on gene therapies in the USA25 — which partly explains why there was such a push to deliver the unsafe mRNA platform onto the market and open up a large new drug sector).

In distinction, DMSO is nearly free and has been proven to deal with many of those issues we nonetheless don’t have a great choice for.

Collagen Issues

Irregular collagen buildup contributes to many illnesses, together with rheumatologic and degenerative growing older circumstances. DMSO, identified for addressing protein buildup, additionally “softens” collagen, benefiting numerous collagen issues. It helps by:

  • Regulating MMP-9 exercise to help orderly therapeutic, lowering fibrotic illnesses.26
  • Decreasing adhesions from surgical procedure27 and eliminating radiation-induced fibrosis.28
  • Treating keloids29 by loosening collagen bundles30 to flatten scars.
  • Strengthening incisions31 and scars to forestall extreme scar formation32 post-surgery.

Word: Many different stories of DMSO benefitting collagen issues (e.g., this symposium, which offered information on 9,521 sufferers with quite a lot of circumstances akin to Dupuytren’s contractures33) additionally exist.

DMSO has proven promising results on collagen-related issues like Dupuytren’s and Peyronie’s, each of which contain irregular collagen buildup. Early research, together with one from 1965,34 confirmed that DMSO improved vary of movement in scleroderma and lowered plaque in Dupuytren’s contracture.

Dupuytren’s Contracture

dupuytrens contracture

This situation entails thickened collagen within the palm, inflicting finger contractures. Customary remedies like collagen-digesting injections, needle aponeurotomy, or surgical procedure can have issues and excessive recurrence charges.35 Early stories famous that long-term DMSO use led to enhancements, with 3 out of three sufferers responding positively in a single research,36 and partial or full remissions in others.37

Nevertheless, effectiveness appears greater when DMSO is used early, at greater concentrations, and over a chronic interval.

Peyronie’s Illness

peyronies disease

Peyronie’s causes painful scarring and curvature of the penis, and whereas remedies exist, they typically do not absolutely resolve the problem. DMSO, particularly when utilized early, has been reported to cut back plaque measurement and ache. Notably, Dr. Stanley Jacob in Portland noticed aid in about half of his sufferers.38 Analysis from the Cleveland Urologists discovered that 6 of 13 males noticed sufficient enchancment to renew regular intercourse,39 with some experiencing lowered plaques and even full decision.

Word: Whereas DMSO doesn’t have a 100% remedy fee for Dupuytren’s or Peyronie’s, it typically works and in contrast to the opposite choices is devoid of unintended effects. As a result of DMSO works finest when used early and could be utilized discreetly at residence, it provides a robust and accessible choice for these coping with these circumstances — particularly Peyronie’s illness.

Rheumatoid Arthritis Contractures

DMSO has additionally confirmed helpful for flexion contractures from rheumatoid arthritis, the place it elevated joint flexibility by 20 to 30 levels with out relapse after a follow-up.40

Fibrodysplasia Ossificans Progressiva (FOP)

fibrodysplasia ossificans progressiva

FOP, a uncommon genetic dysfunction inflicting muscular tissues and ligaments to progressively flip into bone, is often thought of terminal and incurable. But, sufferers in research have improved from DMSO (e.g., one regained some shoulder and hand motion and noticed smaller calcified lumps).41

Scleroderma

“Throughout the eight months I’ve been testing DMS:

  • I’ve been in a position to stroll and drive a automobile (I had been consigned to a wheelchair by medical doctors on the College of Michigan Medical Heart)
  • My horrible swallowing drawback on account of a calcified esophagus has improved, though I nonetheless eat child meals meats
  • I nonetheless have 9 fingers left, free so removed from amputation

I am combating for a change in drug analysis to provide hundreds of different folks a way forward for some promise.”42

Scleroderma is a devastating illness characterised by hardening and thickening of the pores and skin, beginning with blood vessels and doubtlessly spreading to muscular tissues, joints, and inside organs, the place it typically turns into deadly.43 Regardless of years of analysis, choices stay restricted, with poor survival charges and frequent issues like ulcers, impaired mobility, and lack of fingers or toes on account of poor circulation.44

Early analysis discovered DMSO to be remarkably useful for scleroderma, typically prompting affected person protests towards the FDA’s refusal to approve it.45 Research confirmed DMSO’s effectiveness in therapeutic ulcers, softening hardened pores and skin, bettering circulation, and even lowering collagen buildup.

In a landmark research of 42 scleroderma sufferers,46 62% skilled notable enhancements, with a couple of even reaching remission. Many sufferers needed to proceed DMSO use to keep up advantages, however the outcomes have been life-changing.

Word: This research was initially impressed by the popularity that DMSO may be very efficient at treating ache, and scleroderma is commonly fairly painful.

In a later research on the Cleveland Clinic, DMSO elevated joint flexibility, restored pores and skin suppleness, and improved grip energy.47 Russian researchers additionally noticed fast enhancements in over 90% of scleroderma sufferers, with many experiencing no relapses as much as 5 years later.48

dmso six weeks

Testimonials from sufferers, together with a passionate plea earlier than Congress, highlighted DMSO’s potential as a secure and impactful remedy — although it is nonetheless uncommon for contemporary rheumatologists to know a lot about it.49 Moreover, quite a few rheumatologists surveyed by Congress discovered it efficient for scleroderma.50

Different Autoimmune Situations

Within the first two elements of this sequence51,52 I offered intensive analysis demonstrating DMSO’s skill to forestall or resolve experimentally induced irritation (or tissue necrosis) and analysis mapping out DMSO’s particular anti-inflammatory properties (e.g., it inhibits quite a few inflammatory cytokines), and a wealth of knowledge exhibiting it was an efficient remedy for rheumatoid arthritis.

DMSO in flip, is nicely acknowledged for its anti-inflammatory actions, and a few of my colleagues have used it for this function for years. Likewise, many authors have mentioned its use in quite a lot of autoimmune issues (e.g., this writer mentioned how DMSO can typically be fairly useful for idiopathic thrombocytopenic purpura53). Within the part under, I’ll focus on its use in a couple of key autoimmune circumstances.

1. Interstitial cystitis (IC)

• Overview — IC, often known as painful bladder syndrome, can drastically have an effect on high quality of life, resulting in frequent and pressing urination — typically as much as 50 occasions a day — typically accompanied by pelvic ache, bladder irritation, and even blood within the urine.

• DMSO remedy — Administered as RIMSO-50, DMSO has FDA approval particularly for IC. It really works by assuaging ache54 and lowering irritation55 within the bladder wall, selling leisure of bladder muscular tissues56 and stopping scar tissue formation.57

• Outcomes — Medical stories present that many sufferers expertise substantial aid, with response charges various between research however typically demonstrating a major discount in signs akin to ache and urgency.58,59,60,61,62

2. Lupus

• Overview — Lupus is a fancy autoimmune illness that may trigger widespread irritation and injury to numerous physique techniques. Sufferers typically battle with power signs and discover conventional remedies insufficient.

• DMSO functions — Studies recommend that DMSO could successfully alleviate signs in lupus sufferers, even these unresponsive to steroids. Notably, some instances have proven DMSO resulting in remission of lupus-related interstitial cystitis,63 demonstrating its multifaceted advantages.

• Potential impression — As a possible different or adjunct remedy,64 DMSO provides hope for these searching for higher administration of their lupus signs.

3. Bronchial asthma

• Overview — Bronchial asthma is characterised by irritation and narrowing of the airways, resulting in problem respiratory. Conventional remedies typically depend on bronchodilators and corticosteroids.

• DMSO advantages — Analysis signifies that DMSO could scale back the severity of bronchial asthma signs, significantly when used at the side of different therapies. Some research report65 that DMSO can lower the frequency and dosage of bronchial asthma drugs required, with some sufferers even eliminating the necessity for drugs altogether.

• Impression — This might considerably improve the standard of life for bronchial asthma victims, offering them with extra management over their situation.

4. A number of sclerosis (MS)

• Overview — MS is a power illness affecting the central nervous system, resulting in a variety of neurological signs that may differ tremendously between people and sometimes can’t be absolutely managed with typical care.

• DMSO advantages — A Russian research of 34 MS sufferers discovered DMSO offered important profit to them.66

• DMSO case research — Anecdotal proof reveals that some MS sufferers have skilled exceptional enhancements following DMSO remedy.67

Word: There was additionally a reported case68 of Stanley Jacob treating a affected person with ALS which resulted in “some on the spot, in a single day and barely delayed wonders of remedy,” and this consumer reported69 she noticed it visibly enhance the situation. In our personal expertise IV DMSO is without doubt one of the solely issues which may deal with ALS (sometimes it halts the development of the illness).

5. Uveitis

• Overview — Uveitis is an irritation of the center layer of the attention, which may trigger ache, mild sensitivity, and imaginative and prescient adjustments.

• DMSO analysis — Research carried out on canine with uveitis have proven that DMSO successfully reduces each irritation and intraocular strain.70

• Human software potential — This promising analysis means that DMSO might be explored as a remedy choice for people affected by comparable inflammatory eye circumstances, significantly since DMSO treats many different ocular issues.

6. Inflammatory bowel illnesses (IBD)

• Overview — Situations like gastritis, ulcerative colitis and Crohn’s illness result in power irritation of the digestive tract, leading to signs like belly ache, diarrhea, and fatigue.

• Efficacy of DMSO — Analysis highlights DMSO’s potential to cut back relapse charges and inflammatory markers when added to plain therapies for ulcerative colitis.71

• Medical significance — By enhancing the effectiveness of present remedies, DMSO could present a pathway to higher administration of IBD72 and improved affected person outcomes. A lot of my colleagues discover DMSO is exceptionally useful for IBD.

7. Myasthenia gravis (MG)

• Overview — MG is an autoimmune dysfunction that impacts communication between nerves and muscular tissues, resulting in weak point and fatigue.

• DMSO mechanism — Animal research point out that DMSO can scale back ranges of acetylcholine receptor antibodies,73 which play a vital position within the illness’s pathology.

• Future instructions — Whereas human research are missing, this analysis opens the door for potential therapeutic methods involving DMSO in managing MG.

Word: DMSO has additionally been proven to suppress thyroid autoantibodies74 (a standard reason for hypothyroidism).

8. Sjogren’s syndrome — Sjogren’s syndrome (autoimmunity of the parotid gland) ends in a lack of saliva and the mouth changing into very dry. Since it’s a very tough situation to deal with, this desk inside a bigger research75 caught my eye:

dmso efficacy

Conclusion

On the time these discoveries have been made greater than fifty years in the past, they have been revolutionary, many nonetheless are (e.g., typical medication nonetheless can not deal with lots of the circumstances described right here and clinically, DMSO stays one of the anti-inflammatory brokers accessible to us).

Because of this, many physicians and determined sufferers from across the nation fought to make DMSO be legalized, however outdoors of its slender indication for interstitial cystitis, the FDA refused to relent76 — even after many congressional representatives and senators spent many years making an attempt to power the FDA to.

Somewhat, it was solely after the general public turned so disgusted with the FDA conducting police type raids towards pure medication and Congress handed the 1994 DSHEA Act77 which prohibited the FDA from regulating naturally occurring dietary supplements that issues modified (as DMSO happens in nature).

Sadly, by the point this occurred, the injury was carried out and only a few remembered the unbelievable potential DMSO needed to remodel all the observe of drugs — regardless of the actual fact tons of of hundreds of Individuals have been utilizing DMSO within the not too distant previous.

Worse nonetheless, these monopolistic ways by no means stopped, and so many exceptional therapies which might have helped all of humanity have been erased by the medical trade (e.g., contemplate how arduous the FDA fought to bury hydroxychloroquine and ivermectin throughout COVID-19 so the unconscionable mRNA vaccines would face no competitors).

Fortuitously (because of the fast diffusion of data facilitated by social media), these ways have provoked such a powerful backlash that a rare, a once-in-a-lifetime alternative has been created, and subsequent week we are going to finally have an opportunity to repair this dysfunctional paradigm:

In flip, I really feel extremely blessed to stay in an period the place The Forgotten Sides of Drugs can finally be rediscovered and to have been given the chance by the pure well being neighborhood to assist make that occur. For many years I by no means imagined what we’re seeing now might ever be doable.

Creator’s notice: That is an abridged model of an extended article that goes into better element on the factors talked about right here, examines the weird mechanisms that enable DMSO to deal with so many alternative inflammatory circumstances, and offers steering for private DMSO use (e.g., dosing, therapeutic precautions and the place to acquire it).

That article and its further references could be learn right here (together with a companion article discussing DMSO’s life-changing utility for quite a lot of musculoskeletal accidents and power ache circumstances).

A Word from Dr. Mercola In regards to the Creator

A Midwestern Physician (AMD) is a board-certified doctor from the Midwest and a longtime reader of Mercola.com. I admire AMD’s distinctive perception on a variety of matters and am grateful to share it. I additionally respect AMD’s need to stay nameless since AMD continues to be on the entrance traces treating sufferers. To search out extra of AMD’s work, make sure you take a look at The Forgotten Aspect of Drugs on Substack.



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